Article
Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2003
Gibson Michael K, Abraham Susan C, Wu Tsung-Teh, Burtness Barbara, Heitmiller Richard F, Heath Elisabeth, Forastiere Arlene
Abstract excerpt
PURPOSE: Despite the availability of cellular markers associated with cell cycle, apoptosis, and DNA repair, predictive factors for pathological complete response (CR) and overall survival (OS) are few in patients with locally advanced esophageal cancer. This study evaluates the role of clinical and cellular markers in predicting CR and OS in patients with esophageal cancer. EXPERIMENTAL DESIGN: Patients were...
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