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Article

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.

Archives of biochemistry and biophysics - 1 Jan 2023

Tran Michelle, Signorelli Rachel L, Yamaguchi Adriana, Chen Eefie, Holinstat Michael, Iavarone Anthony T, Offenbacher Adam R, Holman Theodore

Abstract excerpt

Human platelet 12-lipoxygenase (h12-LOX) is responsible for the formation of oxylipin products that play an important role in platelet aggregation. Single nucleotide polymorphisms (SNPs) of h12-LOX have been implicated in several diseases. In this study, we investigate the structural, dynamical, and functional impact of a h12-LOX SNP that generates a tyrosine-to-cysteine mutation at a buried site (Y649C h12-LOX)...

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Share to Arachidonate 12-Lipoxygenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36442529
DOI: 10.1016/j.abb.2022.109472
PMCID: PMC9888433

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