Article
Detection, validation, and downstream analysis of allelic variation in gene expression.
Genetics - 1 Jan 2010
Ciobanu Daniel C, Lu Lu, Mozhui Khyobeni, Wang Xusheng, Jagalur Manjunatha, Morris John A, Taylor William L, Dietz Klaus, Simon Perikles, Williams Robert W
Abstract excerpt
Common sequence variants within a gene often generate important differences in expression of corresponding mRNAs. This high level of local (allelic) control-or cis modulation-rivals that produced by gene targeting, but expression is titrated finely over a range of levels. We are interested in exploiting this allelic variation to study gene function and downstream consequences of differences in expression dosage....
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