Article
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
Human molecular genetics - 15 Oct 2011
Wood Andrew R, Hernandez Dena G, Nalls Michael A, Yaghootkar Hanieh, Gibbs J Raphael, Harries Lorna W, Chong Sean, Moore Matthew, Weedon Michael N, Guralnik Jack M, Bandinelli Stefania, Murray Anna, Ferrucci Luigi, Singleton Andrew B, Melzer David, Frayling Timothy M
Abstract excerpt
The identification of multiple signals at individual loci could explain additional phenotypic variance ('missing heritability') of common traits, and help identify causal genes. We examined gene expression levels as a model trait because of the large number of strong genetic effects acting in cis. Using expression profiles from 613 individuals, we performed genome-wide single nucleotide polymorphism (SNP)...
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