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Article

Fine-scale variation and genetic determinants of alternative splicing across individuals.

PLoS genetics - 1 Dec 2009

Coulombe-Huntington Jasmin, Lam Kevin C L, Dias Christel, Majewski Jacek

Abstract excerpt

Recently, thanks to the increasing throughput of new technologies, we have begun to explore the full extent of alternative pre-mRNA splicing (AS) in the human transcriptome. This is unveiling a vast layer of complexity in isoform-level expression differences between individuals. We used previously published splicing sensitive microarray data from lymphoblastoid cell lines to conduct an in-depth analysis on...

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Identifiers

PMID: 20011102
DOI: 10.1371/journal.pgen.1000766
PMCID: PMC2780703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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