Article
Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2016
Lee Euna, Cho Eunjoo, Kang Doo Hyun, Jeong Eun Hee, Chen Zheng, Yoo Seung-Hee, Kim Eun Young
Abstract excerpt
Circadian clocks are composed of transcriptional/translational feedback loops (TTFLs) at the cellular level. In Drosophila TTFLs, the transcription factor dCLOCK (dCLK)/CYCLE (CYC) activates clock target gene expression, which is repressed by the physical interaction with PERIOD (PER). Here, we show that amino acids (AA) 657-707 of dCLK, a region that is homologous to the mouse Clock exon 19-encoded region, is...
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