Article
Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2016
Lee Euna, Cho Eunjoo, Kang Doo Hyun, Jeong Eun Hee, Chen Zheng, Yoo Seung-Hee, Kim Eun Young
Abstract excerpt
Circadian clocks are composed of transcriptional/translational feedback loops (TTFLs) at the cellular level. In Drosophila TTFLs, the transcription factor dCLOCK (dCLK)/CYCLE (CYC) activates clock target gene expression, which is repressed by the physical interaction with PERIOD (PER). Here, we s...
Topics
- Animals
- Biological Clocks
- CLOCK Proteins
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Mice
- Mutation
- Neurons
- Period Circadian Proteins
- Temperature