Article
Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.
Genesis (New York, N.Y. : 2000) - 1 Dec 2009
Festing Maria H, Speer Mei Y, Yang Hsueh-Ying, Giachelli Cecilia M
Abstract excerpt
Accelerated vascular calcification occurs in several human diseases including diabetes and chronic kidney disease (CKD). In patients with CKD, vascular calcification is highly correlated with elevated serum phosphate levels. In vitro, elevated concentrations of phosphate induced vascular smooth muscle cell matrix mineralization, and the inorganic phosphate transporter-1 (PiT-1), was shown to be required. To...
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