Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.

PloS one - 1 Jan 2013

Bourgine Annabelle, Pilet Paul, Diouani Sara, Sourice Sophie, Lesoeur Julie, Beck-Cormier Sarah, Khoshniat Solmaz, Weiss Pierre, Friedlander Gérard, Guicheux Jérôme, Beck Laurent

Abstract excerpt

The formation of hydroxyapatite crystals and their insertion into collagen fibrils of the matrix are essential steps for bone mineralization. As phosphate is a main structural component of apatite crystals, its uptake by skeletal cells is critical and must be controlled by specialized membrane proteins. In mammals, in vitro studies have suggested that the high-affinity sodium-phosphate cotransporter PiT1 could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Body Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Calcification, Physiologic

Share to Gene Expression Regulation

Share to Mice, Transgenic

Share to Radiography

Share to Sodium-Phosphate Cotransporter Proteins, Type III

Source

Open in PubMed Open full text

Identifiers

PMID: 23785462
DOI: 10.1371/journal.pone.0065979
PMCID: PMC3681848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.PMID 23785462Read ↗

The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development.Semantic proximity Read ↗

Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.Semantic proximity Read ↗

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.Semantic proximity Read ↗

Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.Semantic proximity Read ↗

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeletonSemantic proximity Read ↗

Homozygous Loss-of-Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities.Semantic proximity Read ↗

Skeletal Development of Mice Lacking Bone Sialoprotein (BSP) - Impairment of Long Bone Growth and Progressive Establishment of High Trabecular Bone MassSemantic proximity Read ↗

In Vivo Overexpression of Tissue-Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of OsteopontinSemantic proximity Read ↗

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.Semantic proximity Read ↗

Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?Semantic proximity Read ↗

An Essential Physiological Role for MCT8 in Bone in Male Mice.Semantic proximity Read ↗

Altered osteoclast development and function in osteopontin deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.