Article

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton

2026-02-26

Abstract excerpt

Biomineralisation is essential for skeletal integrity, yet the synergistic roles of tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 in postnatal bone mineralisation remain poorly defined. To decipher this, we generated a novel murine model in which Alpl was deleted in Prx1 - expressing cells ( Alpl Prx1/Prx1 ) in mice with a global Phospho1 -/- deficiency to overcome the perinatal lethality that a...

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Literature Corpus work: e14738a5-9b52-5033-88f4-c268534c77ba
DOI: 10.64898/2026.02.25.707785

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