Article
Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia.
Leukemia research - 1 Nov 2009
Xiong Xiujuan, Wang Min, Wang Lin, Liu Jiazhuo, Zhao Xin, Tian Zheng, Wang Jianxiang
Abstract excerpt
A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary...
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