Article
Germline polymorphism of p53 codon 72 in gynecological cancer.
Gynecologic oncology - 1 Jan 2006
Ueda Masatsugu, Terai Yoshito, Kanda Koji, Kanemura Masanori, Takehara Mikio, Yamaguchi Hiroyuki, Nishiyama Koji, Yasuda Masayuki, Ueki Minoru
Abstract excerpt
OBJECTIVE: To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer. METHODS: p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: When...
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