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Article

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1990

Dang L H, Michalek M T, Takei F, Benaceraff B, Rock K L

Abstract excerpt

We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured with murine T-T hybridomas in the presence of specific Ag. During these cocultures, the T-T hybridomas kill the competent APC, allowing the outgrowth of inactive variants. Two variants, A20.M1 and A20.M2, were isolated and...

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PMID: 1971292

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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