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Article

Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.

Biochemistry - 1 Dec 2009

Sajid Waseem, Holst Patricia A, Kiselyov Vladislav V, Andersen Asser S, Conlon J Michael, Kristensen Claus, Kjeldsen Thomas, Whittaker Jonathan, Chan Shu J, De Meyts Pierre

Abstract excerpt

The insulin from the Atlantic hagfish (Myxine glutinosa) has been one of the most studied insulins from both a structural and a biological viewpoint; however, some aspects of its biology remain controversial, and there has been no satisfying structural explanation for its low biological potency. We have re-examined the receptor binding kinetics, as well as the metabolic and mitogenic properties, of this...

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Identifiers

PMID: 19863112
DOI: 10.1021/bi901269j
PMCID: PMC2781304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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