Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the three conserved valine residues of insulin and a proposal of "isosteric residue".

IUBMB life - 1 Dec 2001

Guo Z Y, Tang Y H, Zhang Z, Feng Y M

Abstract excerpt

To further understand the role of the three conserved Val residues in insulin, B12Val, B18Val, and A3Val, five insulin mutants-[A3Ser]insulin, [B12Thr]insulin, (desB30)[B12Ser]insulin, [B18Thr] insulin, and [B18Leu]insulin--were obtained by means of site-directed mutagenesis and their receptor-binding activities as well as in vivo biological potencies were measured. The two B18 mutants, [B18Thr]insulin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Conserved Sequence
Share to Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoleucine

Share to Protein Precursors

Share to Spectrometry, Mass, Electrospray Ionization

Share to Threonine

Share to Valine

Source

Identifiers

PMID: 11895080
DOI: 10.1080/152165401317291165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the three conserved valine residues of insulin and a proposal of "isosteric residue".PMID 11895080Read ↗

Mutagenesis of the three conserved valine residues: consequence on the foldability of insulin.Semantic proximity Read ↗

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Semantic proximity Read ↗

Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule.Semantic proximity Read ↗

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.Semantic proximity Read ↗

Alanine scanning mutagenesis of insulin.Semantic proximity Read ↗

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions.Semantic proximity Read ↗

Role of disulfide bonds in the structure and activity of human insulin.Semantic proximity Read ↗

Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.Semantic proximity Read ↗

Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.Semantic proximity Read ↗

Toward the insulin-IGF-I intermediate structures: functional and structural properties of the [TyrB25NMePheB26] insulin mutant.Semantic proximity Read ↗

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.Semantic proximity Read ↗

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.