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Article

Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.

The Journal of biological chemistry - 13 Nov 2009

Zhao Ming, Wan Zhu-li, Whittaker Linda, Xu Bin, Phillips Nelson B, Katsoyannis Panayotis G, Ismail-Beigi Faramarz, Whittaker Jonathan, Weiss Michael A

Abstract excerpt

Insulin binds with high affinity to the insulin receptor (IR) and with low affinity to the type 1 insulin-like growth factor (IGF) receptor (IGFR). Such cross-binding, which reflects homologies within the insulin-IGF signaling system, is of clinical interest in relation to the association between hyperinsulinemia and colorectal cancer. Here, we employ nonstandard mutagenesis to design an insulin analog with...

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Identifiers

PMID: 19773552
DOI: 10.1074/jbc.M109.028399
PMCID: PMC2797288

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Source receipt: pubmed, retrieved 7 Sept 2026.

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