Article
Specificities mediated by neighboring nucleotides appear to underlie mutation induced by antifolates in E. coli.
Mutation research - 1 Jan 1991
Veigl M L, Schneiter S, Mollis S, Sedwick W D
Abstract excerpt
The antifolate, trimethoprim (TRMP, 5 microM) caused a 10-fold increase in mutation frequency and primarily induced base substitution and deletion mutations in wild-type E. coli. Base-substitutions induced by antifolates were equally divided between transition and transversion mutations. When mutations consistent with expected antifolate-induced deoxynucleotide pool imbalances were considered, 29 out of 32...
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