Article
Specificities mediated by neighboring nucleotides appear to underlie mutation induced by antifolates in E. coli.
Mutation research - 1 Jan 1991
Veigl M L, Schneiter S, Mollis S, Sedwick W D
Abstract excerpt
The antifolate, trimethoprim (TRMP, 5 microM) caused a 10-fold increase in mutation frequency and primarily induced base substitution and deletion mutations in wild-type E. coli. Base-substitutions induced by antifolates were equally divided between transition and transversion mutations. When mut...
Topics
- Base Sequence
- DNA
- DNA Mutational Analysis
- DNA Repair
- Escherichia coli
- Lac Operon
- Molecular Sequence Data
- Mutation
- Nucleotides
- Polymerase Chain Reaction
- Trimethoprim