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Article

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

27 Oct 2009

Abstract excerpt

BACKGROUND: An effective cancer therapeutic must selectively target tumours with minimal systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would enable spatial and temporal control of delivery because these bacteria preferentially target tumours over normal tissue. METHODS: We engineered non-pathogenic S. typhimurium to secrete murine TNF-related apoptosis-inducing ligand (TRAIL)...

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PMID: 19861961
DOI: 10.1038/sj.bjc.6605403

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