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Article

TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death

1 Dec 2008

Abstract excerpt

We have identified TNFSF10 (TRAIL) as a p53-transcriptional target gene. There are two p53 DNA-binding sites in the human TNFSF10 promoter region, at 346 and 625 bp upstream of the transcription start site. A human p53-expressing adenovirus (Ad-p53) induced TRAIL mRNA and protein expression in HCT116 p53-/- human colon cancer cells. A human TRAIL-promoter reporter assay showed increased luciferase activity with...

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PMID: 19106633
DOI: 10.4161/cbt.7.12.7460

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