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Article

Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.

Radiation research - 1 Oct 2009

Martin Lynn, Marples Brian, Coffey Mary, Lawler Mark, Hollywood Donal, Marignol Laure

Abstract excerpt

Low-dose hyper-radiosensitivity (HRS) is the phenomenon whereby cells exposed to radiation doses of less than approximately 0.5 Gy exhibit increased cell killing relative to that predicted from back-extrapolating high-dose survival data using a linear-quadratic model. While the exact mechanism remains to be elucidated, the involvement of several molecular repair pathways has been documented. These processes in...

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Source

Identifiers

PMID: 19772461
DOI: 10.1667/RR1717.1

Genes

MGMT
MLH1
MSH2
MSH6
PMS1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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