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DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated Damage

16 Dec 2004

Abstract excerpt

Previous studies from our laboratory indicated that expression of the MLH1 DNA mismatch repair (MMR) gene was necessary to restore cytotoxicity and an efficient G(2) arrest in HCT116 human colon cancer cells, as well as Mlh1(-/-) murine embryonic fibroblasts, after treatment with 5-fluoro-2'-deoxyuridine (FdUrd). Here, we show that an identical phenomenon occurred when expression of MSH2, the other major MMR...

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PMID: 15611052
DOI: 10.1074/jbc.m412105200

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