Article
Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.
Current biology : CB - 14 Jan 1999
Durant S T, Morris M M, Illand M, McKay H J, McCormick C, Hirst G L, Borts R H, Brown R
Abstract excerpt
Mismatch repair (MMR) proteins repair mispaired DNA bases and have an important role in maintaining the integrity of the genome [1]. Loss of MMR has been correlated with resistance to a variety of DNA-damaging agents, including many anticancer drugs [2]. How loss of MMR leads to resistance is not...
Topics
- Antineoplastic Agents
- Base Pair Mismatch
- Carboplatin
- Cisplatin
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Doxorubicin
- Drug Resistance, Microbial
- Drug Resistance, Neoplasm
- Endonucleases
- Mutation
- Neoplasm Proteins
- Rad52 DNA Repair and Recombination Protein
- Saccharomyces cerevisiae