Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.

Current biology : CB - 14 Jan 1999

Durant S T, Morris M M, Illand M, McKay H J, McCormick C, Hirst G L, Borts R H, Brown R

Abstract excerpt

Mismatch repair (MMR) proteins repair mispaired DNA bases and have an important role in maintaining the integrity of the genome [1]. Loss of MMR has been correlated with resistance to a variety of DNA-damaging agents, including many anticancer drugs [2]. How loss of MMR leads to resistance is not understood, but is proposed to be due to loss of futile MMR activity and/or replication stalling [3] [4]. We report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Mutation

Share to Neoplasm Proteins

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9889125
DOI: 10.1016/s0960-9822(99)80047-5

Genes

MLH1
MSH2
MSH3
MSH6
PMS1
RAD1
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.PMID 9889125Read ↗

Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Semantic proximity Read ↗

MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches.Semantic proximity Read ↗

Resistance to topoisomerase poisons due to loss of DNA mismatch repairSemantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

Role of Mismatch Repair and MGMT in Response to Anticancer TherapiesSemantic proximity Read ↗

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.Semantic proximity Read ↗

MLH1 deficiency leads to deregulated mitochondrial metabolism.Semantic proximity Read ↗

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.Semantic proximity Read ↗

Loss of DNA mismatch repair in acquired resistance to cisplatin.Semantic proximity Read ↗

The epigenetic response to platinum-induced DNA damage and repairSemantic proximity Read ↗

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.Semantic proximity Read ↗

DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated DamageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.