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Article

Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence.

The Journal of biological chemistry - 15 Jan 1991

Beltzer J P, Fiedler K, Fuhrer C, Geffen I, Handschin C, Wessels H P, Spiess M

Abstract excerpt

Uncleaved signal-anchor sequences of membrane proteins inserted into the endoplasmic reticulum initiate the translocation of either the amino-terminal or the carboxyl-terminal polypeptide segment across the bilayer. Which topology is acquired is not determined by the apolar segment of the signal but rather by the hydrophilic sequences flanking it. To study the role of charged residues in determining the membrane...

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PMID: 1985975

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