Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence.

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Article

Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence.

The Journal of biological chemistry - 15 Jan 1991

Beltzer J P, Fiedler K, Fuhrer C, Geffen I, Handschin C, Wessels H P, Spiess M

Abstract excerpt

Uncleaved signal-anchor sequences of membrane proteins inserted into the endoplasmic reticulum initiate the translocation of either the amino-terminal or the carboxyl-terminal polypeptide segment across the bilayer. Which topology is acquired is not determined by the apolar segment of the signal...

Topics

Amino Acid Sequence
Asialoglycoprotein Receptor
Asialoglycoproteins
Base Sequence
DNA Probes
Electrophoresis, Polyacrylamide Gel
Endoplasmic Reticulum
Membrane Proteins
Molecular Sequence Data
Mutation
Receptors, Immunologic
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1985975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1985975-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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