Article
Evidence for a six-transmembrane domain structure of presenilin 1.
The Journal of biological chemistry - 2 May 1997
Lehmann S, Chiesa R, Harris D A
Abstract excerpt
Mutations in genes encoding presenilin 1 and presenilin 2 account for the majority of cases of early-onset familial Alzheimer's disease. The presenilins have been localized to the endoplasmic reticulum and Golgi, but which of the multiple hydrophobic segments of the polypeptide chain span the lipid bilayer is unclear. To address this question, we have constructed a series of chimeric molecules in which a...
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