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Topology of the C-Terminal Fragment of Human Presenilin 1

13 Aug 2005

Abstract excerpt

Mutations of human presenilin 1 (PS1) have been genetically linked to early-onset familial Alzheimer's disease. PS1 contains 10 hydrophobic regions (HRs) sufficiently long to be alpha-helical membrane spanning segments. Most previous topology studies agree that the N-terminus of PS1 is cytosolic and HRs 1-6 span the membrane but HR 7 does not. However, whether HRs 8 and 9 are membrane spanning segments remains...

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PMID: 16128583
DOI: 10.1021/bi0509494

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