Article
Prediction of signal peptide functional properties: a study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants.
Protein engineering - 1 Apr 1996
Talmud P, Lins L, Brasseur R
Abstract excerpt
A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport. Using molecular modelling of the invertase signal peptide we have analysed the hydrophobicity potential...
Topics
- Amino Acid Sequence
- Apolipoproteins B
- Computer Simulation
- Genetic Variation
- Glycoside Hydrolases
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals
- Structure-Activity Relationship
- Yeasts
- beta-Fructofuranosidase