Article
Plasticity of quaternary structure: twenty-two ways to form a LacI dimer.
Protein science : a publication of the Protein Society - 1 Feb 2001
Swint-Kruse L, Elam C R, Lin J W, Wycuff D R, Shive Matthews K
Abstract excerpt
The repressor proteins of the LacI/GalR family exhibit significant similarity in their secondary and tertiary structures despite less than 35% identity in their primary sequences. Furthermore, the core domains of these oligomeric repressors, which mediate dimerization, are homologous with the monomeric periplasmic binding proteins, extending the issue of plasticity to quaternary structure. To elucidate the...
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