Article
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.
American journal of respiratory and critical care medicine - 1 Feb 2010
Sisson Thomas H, Mendez Michael, Choi Karen, Subbotina Natalya, Courey Anthony, Cunningham Andrew, Dave Aditi, Engelhardt John F, Liu Xiaoming, White Eric S, Thannickal Victor J, Moore Bethany B, Christensen Paul J, Simon Richard H
Abstract excerpt
RATIONALE: Ineffective repair of a damaged alveolar epithelium has been postulated to cause pulmonary fibrosis. In support of this theory, epithelial cell abnormalities, including hyperplasia, apoptosis, and persistent denudation of the alveolar basement membrane, are found in the lungs of humans with idiopathic pulmonary fibrosis and in animal models of fibrotic lung disease. Furthermore, mutations in genes that...
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