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Article

Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.

American journal of respiratory cell and molecular biology - 1 Mar 2016

Garcia Orquidea, Hiatt Michael J, Lundin Amber, Lee Jooeun, Reddy Raghava, Navarro Sonia, Kikuchi Alex, Driscoll Barbara

Abstract excerpt

Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, nonspecific destruction of alveolar epithelia or on targeted, nontitratable levels of fixed AEC2 ablation. We...

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Identifiers

PMID: 26203800
DOI: 10.1165/rcmb.2014-0246OC
PMCID: PMC4821031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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