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Article

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice.

Acta neuropathologica - 1 Jun 2008

De Paepe Boel, Brusselle Guy G, Maes Tania, Creus Kim K, D'hose Sophie, D'Haese Nele, Bracke Ken R, D'hulst An I, Joos Guy F, De Bleecker Jan L

Abstract excerpt

Systemic manifestations of chronic obstructive pulmonary disease (COPD) include muscle wasting, and tumour necrosis factor alpha (TNFalpha) could represent a major inducer of these processes. We studied skeletal muscle histology in a murine model of cigarette smoke (CS)-induced COPD, comparing mice with different TNFalpha receptor genotypes. Muscles from hind limbs of wild type (WT), TNFalpha receptor 1 knockout...

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Source

Identifiers

PMID: 18309502
DOI: 10.1007/s00401-008-0348-4

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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