Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis

24 Dec 2004

Abstract excerpt

Insulin-like growth factor-I (IGF-I) has been implicated in postnatal alveolar development, pulmonary fibrosis, and non-small cell lung cancer. To further investigate the role of IGF-I, we created a line of transgenic mice in which alveolar type II epithelial cells express human IGF-IA under the control of the surfactant protein C promoter. We determined the effect of pulmonary overexpression of human IGF-IA on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Digestive system and related health
Share to Growth Hormone and Insulin-like Growth Factors
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15618451
DOI: 10.1152/ajplung.00420.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosisPMID 15618451Read ↗

Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinomaSemantic proximity Read ↗

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.Semantic proximity Read ↗

Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor.Semantic proximity Read ↗

Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes.Semantic proximity Read ↗

Lung pathology in platelet-derived growth factor transgenic mice: effects of genetic background and fibrogenic agents.Semantic proximity Read ↗

Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5.Semantic proximity Read ↗

Relationship between Lung Carcinogenesis and Chronic Inflammation in RodentsSemantic proximity Read ↗

Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice.Semantic proximity Read ↗

Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.Semantic proximity Read ↗

Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.Semantic proximity Read ↗

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.Semantic proximity Read ↗

Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease: Fig. 1—Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.