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Article

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.

American journal of respiratory cell and molecular biology - 1 Sept 2011

Zhong Qian, Zhou Beiyun, Ann David K, Minoo Parviz, Liu Yixin, Banfalvi Agnes, Krishnaveni Manda S, Dubourd Mickael, Demaio Lucas, Willis Brigham C, Kim Kwang-Jin, duBois Roland M, Crandall Edward D, Beers Michael F, Borok Zea

Abstract excerpt

Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2) cell apoptosis in idiopathic pulmonary fibrosis. We hypothesized that ER stress (either chemically induced or due to accumulation of misfolded proteins) is also associated with epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AECs). ER stress inducers, thapsigargin (TG) or tunicamycin (TN), increased...

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Identifiers

PMID: 21169555
DOI: 10.1165/rcmb.2010-0347OC
PMCID: PMC3175581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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