Article
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2011
Lawson William E, Cheng Dong-Sheng, Degryse Amber L, Tanjore Harikrishna, Polosukhin Vasiliy V, Xu Xiaochuan C, Newcomb Dawn C, Jones Brittany R, Roldan Juan, Lane Kirk B, Morrisey Edward E, Beers Michael F, Yull Fiona E, Blackwell Timothy S
Abstract excerpt
Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial pneumonia and (ii) intratracheal treatment with the protein misfolding agent tunicamycin. We...
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