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Article

<i>PDCD4</i> gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis

13 Sept 2008

Abstract excerpt

Programmed cell death 4 (PDCD4) is a newly described tumour suppressor that inhibits oncogenesis by suppressing gene transcription and translation. Loss of PDCD4 expression has been found in several types of human cancers including the most common cancer of the brain, the gliomas. However, the molecular mechanisms responsible for PDCD4 gene silencing in tumour cells remain unclear. Here we report the...

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PMID: 18793349
DOI: 10.1111/j.1582-4934.2008.00497.x

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