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Article

Epigenetic inactivation of secreted Frizzled‐related proteins in acute myeloid leukaemia

5 Jun 2008

Abstract excerpt

The Wnt signalling pathway has a key function in stem cell maintenance and differentiation of haematopoietic progenitors. Secreted Frizzled-related protein genes (SFRPs), functioning as Wnt signalling antagonists, have been found to be downregulated by promoter hypermethylation in many tumours. To analyse epigenetic dysregulation of SFRPs in acute myeloid leukaemia (AML), we examined the promoter methylation...

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PMID: 18537968
DOI: 10.1111/j.1365-2141.2008.07242.x

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