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Article

Frequent promoter hypermethylation and transcriptional downregulation of the <i>NDRG2</i> gene at 14q11.2 in primary glioblastoma

15 Aug 2008

Abstract excerpt

The N-myc downstream-regulated gene 2 (NDRG2) at 14q11.2 has been reported to be downregulated in glioblastoma, and NDRG2 overexpression represses glioblastoma cell proliferation in vitro (Deng et al., Int J Cancer 2003;106;342-7). To further address the role of NDRG2 as a candidate tumor suppressor in human gliomas, we analyzed 67 astrocytic tumors (10 diffuse astrocytomas, 11 anaplastic astrocytomas, 34 primary...

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PMID: 18709645
DOI: 10.1002/ijc.23705

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