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Article

Promoter Hypermethylation-mediated Inactivation of LRRC4 in Gliomas

1 Jan 2008

Abstract excerpt

BACKGROUND: Leucine-rich repeat C4 protein (LRRC4) is a new member of the leucine-rich repeat (LRR) superfamily. It is not only a brain-specific gene but also a novel candidate for tumor suppression. LRRC4 inactivation is commonly found in glioma cell lines and primary glioma biopsies. However, little is known about the mechanism controlling LRRC4 expression. In a previous study, we did not find any genetic...

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PMID: 18976507
DOI: 10.1186/1471-2199-9-99

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