Article
RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas.
Neoplasia (New York, N.Y.) - 1 Jun 2012
von dem Knesebeck Anna, Felsberg Jörg, Waha Anke, Hartmann Wolfgang, Scheffler Björn, Glas Martin, Hammes Jennifer, Mikeska Thomas, Yan Pearlly S, Endl Elmar, Simon Matthias, Reifenberger Guido, Pietsch Torsten, Waha Andreas
Abstract excerpt
Alterations of DNA methylation play an important role in gliomas. In a genome-wide screen, we identified a CpG-rich fragment within the 5' region of the tumor necrosis factor receptor superfamily, member 11A gene (TNFRSF11A) that showed de novo methylation in gliomas. TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB....
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