Article
Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations.
Immunogenetics - 1 Apr 2009
Koskinen Lotta, Romanos Jihane, Kaukinen Katri, Mustalahti Kirsi, Korponay-Szabo Ilma, Barisani Donatella, Bardella Maria Teresa, Ziberna Fabiana, Vatta Serena, Széles György, Pocsai Zsuzsa, Karell Kati, Haimila Katri, Adány Róza, Not Tarcisio, Ventura Alessandro, Mäki Markku, Partanen Jukka, Wijmenga Cisca, Saavalainen Päivi
Abstract excerpt
Human leukocyte antigen (HLA) genes, located on chromosome 6p21.3, have a crucial role in susceptibility to various autoimmune and inflammatory diseases, such as celiac disease and type 1 diabetes. Certain HLA heterodimers, namely DQ2 (encoded by the DQA1*05 and DQB1*02 alleles) and DQ8 (DQA1*03 and DQB1*0302), are necessary for the development of celiac disease. Traditional genotyping of HLA genes is laborious,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.