Article
The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1.
Frontiers in immunology - 1 Jan 2018
Anania Jessica C, Trist Halina M, Palmer Catherine S, Tan Peck Szee, Kouskousis Betty P, Chenoweth Alicia M, Kent Stephen J, Mackay Graham A, Hoi Alberta, Koelmeyer Rachel, Slade Charlotte, Bryant Vanessa L, Hodgkin Philip D, Aui Pei Mun, van Zelm Menno C, Wines Bruce D, Hogarth P Mark
Abstract excerpt
FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) therapy. We aim to define the functional consequences of this FcγRIIa variant associated with...
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