Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2010

Swainson Louise A, Mold Jeff E, Bajpai Urmila D, McCune Joseph M

Abstract excerpt

CD4(+)FoxP3(+) regulatory T cells (T(reg)) play a critical role in maintaining self-tolerance and inhibiting autoimmune disease. Despite being a major focus of modern immunological investigation, many aspects of T(reg) biology remain unknown. In a screen for novel candidate genes involved in human T(reg) function, we detected the expression of an autoimmune susceptibility gene, FcRL3, in T(reg) but not in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Immunologic

Share to Self Tolerance

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 20190142
DOI: 10.4049/jimmunol.0903943
PMCID: PMC2894810

Genes

FCRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.PMID 20190142Read ↗

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.Semantic proximity Read ↗

Regulatory T cells in human autoimmune diseases.Semantic proximity Read ↗

Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression.Semantic proximity Read ↗

A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.Semantic proximity Read ↗

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.Semantic proximity Read ↗

FOXP3+ regulatory T cells in the human immune system.Semantic proximity Read ↗

Control of regulatory T cell development by the transcription factor Foxp3.Semantic proximity Read ↗

Genetic Variations Controlling Regulatory T Cell Development and Activity in Mouse Models of Lupus-Like Autoimmunity.Semantic proximity Read ↗

FOXP3 Mutations and Instability as Determinants of Regulatory T-Cell Plasticity in Endocrine Autoimmunity.Semantic proximity Read ↗

FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.Semantic proximity Read ↗

GARP: a key receptor controlling FOXP3 in human regulatory T cells.Semantic proximity Read ↗

Regulatory B cells in autoimmunity: developments and controversies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.