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Article

The Complex Association of FcγRIIb With Autoimmune Susceptibility.

Frontiers in immunology - 1 Jan 2019

Verbeek J Sjef, Hirose Sachiko, Nishimura Hiroyuki

Abstract excerpt

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and inflammatory responses. The observation 19 years ago that FcγRIIb-/- mice generated by gene targeting in 129 derived ES cells developed severe lupus like disease when backcrossed more than 7 generations into C57BL/6 background initiated extensive research on the functional understanding of this strong autoimmune phenotype. The...

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Identifiers

PMID: 31681256
DOI: 10.3389/fimmu.2019.02061
PMCID: PMC6803437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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