Impact of rs7528684 (-169T/C) on FCRL3, FOXP3, IL-35 Gene Expression and RF correlation: Insights into Rheumatoid Arthritis Pathogenesis

Abstract excerpt

<title>Abstract</title> <p>Background Fc Receptor-Like Protein 3 (<italic>FCRL3</italic>) gene encodes for transmembrane receptor, that predominantly expressed on the surface of the Regulatory T cells (Tregs). The receptor owns two crucial motifs in its cytoplasmic domain, which downregulates the signal transduction of T - cell Receptor (TCR) mediated Tregs activation and proliferation. Single Nucleotide Polymorp...

Topics

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• Arthritis, Rheumatoid
• Asian People
• Case-Control Studies
• China
• Genetic Association Studies
• Polymorphism, Single Nucleotide
• Receptors, Immunologic
• Risk Factors

Identifiers and source

Literature Corpus work

561ae2f5-16cc-5822-9d86-8471e67574a5

DOI

10.21203/rs.3.rs-7393465/v1