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Article

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.

Molecular and cellular biology - 1 Mar 2001

Bruneau B G, Bao Z Z, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire C T, Berul C I, Kass D A, Kuroski-de Bold M L, de Bold A J, Conner D A, Rosenthal N, Cepko C L, Seidman C E, Seidman J G

Abstract excerpt

To define the role of Irx4, a member of the Iroquois family of homeobox transcription factors in mammalian heart development and function, we disrupted the murine Irx4 gene. Cardiac morphology in Irx4-deficient mice (designated Irx4(Delta ex2/Delta ex2)) was normal during embryogenesis and in early postnatal life. Adult Irx4(Delta ex2/Delta ex2) mice developed a cardiomyopathy characterized by cardiac hypertrophy...

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Identifiers

PMID: 11238910
DOI: 10.1128/MCB.21.5.1730-1736.2001
PMCID: PMC86719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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