Article
Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients.
BMC cancer - 27 Mar 2007
Lakatos Peter Laszlo, Hitre Erika, Szalay Ferenc, Zinober Kerstin, Fuszek Peter, Lakatos Laszlo, Fischer Simon, Osztovits Janos, Gemela Orsolya, Veres Gabor, Papp Janos, Ferenci Peter
Abstract excerpt
BACKGROUND: Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer (CRC) and mutations of the NOD2/CARD15 gene increase the risk for Crohn's disease (CD). Recently, NOD2/CARD15 has been associated with a risk for CRC in some studies,...
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