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Article

Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2005

Weidinger S, Klopp N, Rümmler L, Wagenpfeil S, Baurecht H J, Gauger A, Darsow U, Jakob T, Novak N, Schäfer T, Heinrich J, Behrendt H, Wichmann H E, Ring J, Illig T

Abstract excerpt

BACKGROUND: Influences of microbial pathogens are crucial for the maturation of the immune system. Caspase-recruitment domain containing protein 15 (CARD15) is a cytosolic receptor involved in bacterial recognition by antigen-presenting cells. CARD15 polymorphisms have been associated with Crohn's disease. Recently, associations with atopic phenotypes have been reported in children. OBJECTIVE: Within a large...

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PMID: 16008671
DOI: 10.1111/j.1365-2222.2005.02269.x

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