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Article

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS.

Pharmacogenetics and genomics - 1 Jan 2012

Liptrott Neill J, Pushpakom Sudeep, Wyen Christoph, Fätkenheuer Gerd, Hoffmann Christian, Mauss Stefan, Knechten Heribert, Brockmeyer Norbert H, Hopper-Borge Elizabeth, Siccardi Marco, Back David J, Khoo Saye H, Pirmohamed Munir, Owen Andrew

Abstract excerpt

BACKGROUND: Nevirapine exhibits marked interpatient variability in pharmacokinetics. CYP2B6 activity and demographic factors are important, but there are a few data on drug transporters for nevirapine. ABCC10 (MRP7) is an efflux transporter highly expressed in liver, intestine, and peripheral blood cells. We investigated whether nevirapine is a substrate for ABCC10 and whether genetic variants contribute to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22082652
DOI: 10.1097/FPC.0b013e32834dd82e
PMCID: PMC3605700

Genes

ABCC10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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