Article
Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo.
Pharmacogenetics - 1 Apr 2001
Xie H G, Dishy V, Sofowora G, Kim R B, Landau R, Smiley R M, Zhou H H, Wood A J, Harris P, Stein C M
Abstract excerpt
There are marked interethnic differences in beta 1-adrenoceptor-mediated responsiveness, with sensitivity decreased in African-Americans and increased in Chinese compared with Caucasians. Therefore, the frequency of a common naturally occurring polymorphism of the human beta 1-adrenoceptor gene (Arg389Gly), which has functional importance in vitro, was determined in 194 African-Americans, 316 Caucasian-Americans,...
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