Article
An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy.
European heart journal - 1 Jul 2002
White H L, Maqbool A, McMahon A D, Yates L, Ball S G, Hall A S, Balmforth A J
Abstract excerpt
AIMS: The Glycine389 variant of the beta-1 adrenergic receptor generates markedly less cAMP when stimulated in vitro than the more prevalent Arginine389 variant and may confer protection against coronary events similar to that observed with beta-blockers. The aim of this study was to ascertain whether this Glycine389 variant protects against coronary events. METHODS AND RESULTS: We identified the genotype at...
Topics
- Adult
- Alleles
- Base Sequence
- Case-Control Studies
- Chi-Square Distribution
- Confidence Intervals
- Genetic Predisposition to Disease
- Genotype
- Humans
- Logistic Models
- Longitudinal Studies