Article
The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects.
Clinical science (London, England : 1979) - 1 Sept 2000
O'Shaughnessy K M, Fu B, Dickerson C, Thurston D, Brown M J
Abstract excerpt
Mutation scanning of the beta1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally active polymorphism on clinical response to beta-adrenoceptor blockade. Two cohorts of untreated hypertensive patients randomly assigned to a beta1-selective beta-blocker at the start of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.