Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.

doi:10.1007/s00109-009-0548-y

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Article

Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2010

Fontaine-Bisson Benedicte, Alessi Marie-Christine, Saut Noemie, Fumeron Frederic, Marre Michel, Dutour Anne, Badens Catherine, Levy Nicolas, Tichet Jean, Juhan-Vague Irene, Trégouët David-Alexandre, Balkau Beverly, Morange Pierre-Emmanuel

Abstract excerpt

Laminopathies are rare monogenic diseases, some of them exhibiting features of the metabolic syndrome. These diseases are mainly due to mutations in LMNA, encoding A-type lamins. One LMNA polymorphism, rs4641, has been associated with the metabolic syndrome, but results have been controversial. We therefore investigated the effect of single nucleotide polymorphisms (SNPs) in the LMNA gene in combination with four...

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Identifiers

PMID: 19841875
DOI: 10.1007/s00109-009-0548-y

Genes

LMNA
FNTA
FNTB
ICMT
ZMPSTE24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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